Sodium Hydroxide → HCID 25206961, compound

HRID 1685085Notes

Reaction equation

HRID 1685085 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][CH:33]=1)[CH2:5][NH:6][C:7](=[O:30])[NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][N:15]([CH3:29])[C:16]([C:18]2[C:19]([C:24]([O:26]CC)=[O:25])=[N:20][O:21][C:22]=2[CH3:23])=[O:17])[N:13]=1.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][CH:33]=1)[CH2:5][NH:6][C:7](=[O:30])[NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][N:15]([CH3:29])[C:16]([C:18]2[C:19]([C:24]([OH:26])=[O:25])=[N:20][O:21][C:22]=2[CH3:23])=[O:17])[N:13]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 25207597HCID 25207597, compound

Product 1

HCID 25206961HCID 25206961, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Example: Ethyl 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)-carbamoyl)-5-methylisoxazole-3-carboxylate (105 mg) was dissolved in ethanol (5 ml) and 1 N sodium hydroxide (5.0 eq) was added and stirred for 2 hours. The reaction was acidified to pH=2 and concentrated. The precipitate was filtered, washed with water and dried to give 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylic acid.

Workup

  1. concentrationconcentrated
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-b1a8c33623e94ddcab157e1c78becd2d
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

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