Dimethylamine → HCID 86661324, compound

HRID 1685094Notes

Reaction equation

HRID 1685094 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH2:5][NH:6][C:7](=[O:28])[NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][N:15]([CH3:27])[C:16]([C:18]2[CH:23]=[C:22]([O:24][CH3:25])[N:21]=[N:20][C:19]=2Cl)=[O:17])[N:13]=1.[CH3:32][NH:33][CH3:34]>O1CCOCC1>[CH3:32][N:33]([CH3:34])[C:19]1[N:20]=[N:21][C:22]([O:24][CH3:25])=[CH:23][C:18]=1[C:16]([N:15]([CH2:14][C:12]1[N:13]=[C:9]([NH:8][C:7]([NH:6][CH2:5][C:4]2[CH:29]=[CH:30][CH:31]=[C:2]([F:1])[CH:3]=2)=[O:28])[S:10][CH:11]=1)[CH3:27])=[O:17]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 86661317HCID 86661317, compound

Product 1

HCID 86661324HCID 86661324, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-Chloro-6-methoxypyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide was treated with dimethylamine in 1,4-dioxane to afford the desired product.

Sources & evidence

ORD record
ord-06929b2164754d48bd4a470692a0b499
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

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