HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetonitrile → HCID 44542641, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | Methyl 3-amino-5-bromo-1-benzothiophene-2-carboxylate | HCID 44542789 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 44542641 | HCID 44542641 | — |
Reaction Steps
A suspension of EXAMPLE 1A (7.2 g, 25.16 mmol) in 4N hydrochloric acid in dioxane (70 mL) was treated with 2-chloroacetonitrile (3.18 mL, 50.32 mmol) at ambient temperature for 3 hours. The white solid was collected by filtration and dried to give the title compound as the hydrochloride salt. LCMS (APCI) m/z: 362(M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148384B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f5122d728e384fb5b448e893fe3bb9a7 |
| Source note | uspto-grants-2012_04 |