HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1685117Generated: October 31, 2026
1,2-Dichloroethane → HCID 67264809, compound
https://huagongshe.com/reaction/1685117
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl (3R)-3-(aminomethyl)-4-benzylpiperazine-1-carboxylate | HCID 57415720 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67264809 | HCID 67264809 | 79% |
Reaction Steps
Into a 50 mL round bottom flask was added 15S (820 mg, 2.68 mmol) and dichloromethane (15 mL). Benzoic acid (15T) (426 mg, 1.3 eq) and EDC (669 mg, 1.3 eq) was added and the flask was cooled to 0° C. DIEA (1.04 g, 3 equiv.) was slowly added and the reaction was stirred at room temperature overnight. The solvent was removed under vacuum and the residue was purified by column chromatography with 5% methanol in dichloromethane to give 15U as a solid (865 mg, 79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08148367B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-e62b1632ec91467cbfcaff3b8013fed3 |
|---|
| Source note | uspto-grants-2012_04 |
|---|
