Sodium Chloride → HCID 68052643, compound

Participants

Reaction Steps

To a mixture of N,2-bis(2,4-dimethoxybenzyl)-6-nitroisoindolin-5-amine T-03 (2.7 g, 5.6 mmol) and sodium hydrosulfite (15.6 g, 90 mmol) was added a solution of tetrahydrofuran (40 mL), water (40 mL) and ammonium hydroxide (40 mL). The reaction mixture was stirred at room temperature overnight. The reaction mixture was basified with sodium hydroxide and saturated with sodium chloride. The reaction mixture was filtered and extracted with ethyl acetate. The organic layer was dried over sodium sulfate. Solvent was evaporated under reduced pressure to afford the desired N5,2-bis(2,4-dimethoxybenzyl)isoindoline-5,6-diamine T-04 (2.5 g, 5.6 mmol). The crude product was used in the next step without further purification.

Provenance & Evidence