Diisopropylethylamine → HCID 86651928, compound

Participants

Reaction Steps

To a solution of 4-(4-methoxybenzyloxy)-1-methyl-3-(4-(6-(methylcarbamoyl)pyridin-3-yl)phenyl)-1H-pyrazole-5-carboxylic acid T-13 (304 mg, 0.64 mmol) in N,N-dimethylformamide (4 mL) were added N5,2-bis(2,4-dimethoxybenzyl)isoindoline-5,6-diamine T-04 (347 mg, 0.77 mmol), HATU (318 mg, 0.84 mmol) and diisopropylethylamine (0.34 mL, 2.0 mmol). The reaction mixture was stirred at room temperature for 2 hours. The crude product was diluted with ethyl acetate. The organic layer was washed with water and saturated brine. The organic layer was dried over sodium sulfate. Solvent was evaporated under reduced pressure. The crude product was purified by flash chromatography to afford the desired 5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide T-14 (410 mg, 0.45 mmol).

Provenance & Evidence