HCID 86651928, compound → HCID 136403437, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-(4-(5-(2-(2,4-dimethoxybenzyl)-6-(2,4-dimethoxybenzylamino)isoindolin-5-ylcarbamoyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide T-14 (410 mg, 0.45 mmol) in acetic acid (4 mL) was heated in a microwave reactor at 150° C. for 50 minutes. Solvent was evaporated under reduced pressure and trifluoroacetic acid (4 mL) was added. The reaction mixture was heated in microwave reactor at 120° C. for 30 minutes. Solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to afford the desired 5-(4-(4-hydroxy-1-methyl-5-(1,5,6,7-tetrahydroimidazo[4,5-f]isoindol-2-yl)-1H-pyrazol-3-yl)phenyl)-N-methylpicolinamide T-15 (143 mg, 0.31 mmol).

Provenance & Evidence