Lithium hydroxide, monohydrate → HCID 68052781, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-(4-methoxybenzyloxy)-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazole-5-carboxylate T-21 (440 mg, 1.0 mmol) in methanol (10 mL) was added lithium hydroxide monohydrate (124 mg, 3.0 mmol). The reaction mixture was heated in a microwave reactor at 120° C. for 20 minutes. Solvent was removed under reduced pressure. Ethyl acetate and 0.1 N hydrochloric acid were added. The organic layer was washed with saturated brine. The organic layer was dried over sodium sulfate. Solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to afford the desired 4-(4-methoxybenzyloxy)-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazole-5-carboxylic acid T-22 (100 mg, 0.23 mmol).

Provenance & Evidence