Hydrochloric Acid → HCID 86641603, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve (R)-benzyl 2-((2-(1-(tert-butoxycarbonyl)piperidin-4-yl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)piperidine-1-carboxylate (2.6 g, 0.004 mol, 1.0 eq) in DCM (15 mL). Cool the reaction mass to 0° C. and add HCl (4.0 M in dioxane, 5 mL, 0.020 mol) drop-wise. Allow the reaction to warm up to RT and stir for 16 h. After completion, concentrate the reaction and co-evaporate with methanol (5×20 mL) under high vacuum to get 2.2 g (83.6%) of the title compound. (ES+): m/z=545 (M+H).

Provenance & Evidence