HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 86641605, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 1,3-Thiazole-2-carbaldehyde | HCID 2734903 | — |
| Reactant | 4-chloro-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one | HCID 12095870 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86641605 | HCID 86641605 | 77.8% |
Reaction Steps
Combine 4-chloro-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (0.3 g; 0.0017 mol), thiazole-2-carbaldehyde (0.23 mL, 0.0026 mol) in methanol (1.5 mL). Add drop-wise pyrrolidine (0.073 mL; 0.0008 mol). Stir at RT for 15 min. Filter the solids to give the title compound (0.35 g; 76.08%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148387B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-96b6e7643a0640e5a6e21519c83c5e37 |
| Source note | uspto-grants-2012_04 |