Ammonia → HCID 86641607, compound

HRID 1685180Notes

Reaction equation

HRID 1685180 reaction equation
[Cl:1][C:2]1[C:7]([NH:8][CH3:9])=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[NH3:11]>>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:6]([NH2:11])[C:7]=1[NH:8][CH3:9]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 2502744,6-Dichloro-N-methylpyrimidin-5-amine

Product 1

HCID 86641607HCID 86641607, compoundYield 76.78%

Procedure

Combine 4,6-dichloro-N-methylpyrimidin-5-amine (0.6 g; 0.0034 mol), and liquid ammonia (6 mL) and stir at 80° C. for 4 h. Extract with EA and evaporate to give the title compound (0.41 g; 76.78%).

Workup

  1. extractionExtract with EA
  2. customevaporate

Sources & evidence

ORD record
ord-68c3b315e27748538c175f40828dfc25
Source dataset
uspto-grants-2012_04
Patent number
US08148387B2

Reaction notes

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