Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | HCID 86641607 | HCID 86641607 | — |
| Product | HCID 14518099 | HCID 14518099 | 42% |
Reaction Steps
Add 6-chloro-N5-methyl-pyrimidine-4,5-diamine (0.41 g, 0.0025 mol) to THF (12.3 mL). Cool to 0° C., add TEA (0.51 g; 0.005 mol), triphosgene (0.92 g; 0.0031 mol) and stir at RT for 1 h. Quench with water and extract with EA. Evaporate the organic layer to give the title compound (0.2 g; 42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08148387B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-049592ae6d0d46088b0eb8f4e8e83444 |
|---|
| Source note | uspto-grants-2012_04 |
|---|
