Hydrochloric Acid → (R)-1-Cbz-3-aminopiperidine

Participants

Reaction Steps

Add 4M HCl in dioxane (100 mL) to a solution of (R)-3-tert-butoxycarbonylamino-piperidine-1-carboxylic acid benzyl ester (71.65 mmol; 23.96 g) in DCM (100 mL) and MeOH (10 mL). Stir 60 min and evaporate. Partition solid between DCM and saturated sodium bicarbonate aqueous, extract three times with DCM, Wash extracts with brine, dry over MgSO4, filter through Celite® and evaporate to give the title compound 17.39 g (74.22 mmol; 104%). MS (ES+): m/z=235 (M+H).

Provenance & Evidence