Water → HCID 59322423, compound

Participants

Reaction Steps

Combine (S)-benzyl 2-((4-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(piperidin-4-yl)-1H-imidazol-1-yl)methyl)piperidine-1-carboxylate trihydrochloride (1.1 g, 0.00168 mol, 1.0 eq); 4-chloro-5-ethyl-5,7-dihydro-pyrrolo[2,3d]pyrimidin-6-one (0.4 g, 0.002 mol, 1.2 eq); DIPEA (2 mL, 0.011 mol, 7.0 eq) and 2-propanol (20 mL) in a pressure tube and heat at 120° C. overnight under sealed condition. Cool the reaction mass and dilute with water. Extract in EA and wash the organic layer with brine. Dry over anhydrous sodium sulfate and concentrate the crude compound. Purify on silica gel (100-200 mesh) column using 10% acetone-DCM as eluent. Pool the fractions containing the desired compound and concentrate under vacuum to the title compound. MS (ES+): m/z=706 (M+H).

Provenance & Evidence