Hydrochloric Acid → 4-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-(2-methylamino-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one tris hydrochloride

Participants

Reaction Conditions

Reaction Steps

Dissolve (2-{4-(4-fluoro-3-trifluoromethyl-phenyl)-2-[1-(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidin-4-yl]-imidazol-1-yl}-ethyl)-methyl-carbamic acid benzyl ester (213 μmol; 136 mg) in conc. HCl (8 mL) and heat to 50° C. for 60 min. Cool to RT, extract 2 times with ether, evaporate the organic layer, co-evaporate the residue 2 times with MeOH, co-evaporate the residue 2 times with DCM/MeOH to provide 129.6 mg (0.21 mmol; 99%) of the title compound. MS (ES+): m/z=504 (M+H).

Provenance & Evidence