Hydrochloric Acid → HCID 86641616, compound

Participants

Reaction Conditions

Reaction Steps

Charge (2S)-benzyl 2-((2-(1-(5-ethyl-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)piperidine-1-carboxylate (0.45 g; 1.0 eq) in concentrated HCl (10 mL) and heat at 50° C. for 1 hour. After completion, concentrate the reaction mass, strip with toluene and triturate and wash with diethyl ether followed by DCM and pentane. Dry under vacuum to get 0.39 g (90%) of the title compound as an off-white solid. (ES+): m/z=572 (M+H).

Provenance & Evidence