Dimethylformamide → HCID 59322416, compound

Participants

Reaction Steps

Combine 2-(4-(3,4-difluorophenyl)-2-(piperidin-4-yl)-1H-imidazol-1-yl-N,N-dimethyl ethanamine tris hydrochloride (0.28 g; 0.00064 mol), 4-chloro-5,5-dimethyl-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (0.15 g; 0.00076 mol), TEA (0.74 mL; 0.0053 mol) in DMF (8.43 mL) and heat in microwave at 150° C. for 3 h; cool to RT and evaporate under vacuum. Quench the reaction with saturated sodium bicarbonate solution and extract with EA. Evaporate the EA layer and purify on silica column (60-120 mesh) packed in DCM, first with two volumes of 10% Acetone/DCM followed by 1-5% MeOH/DCM as eluent to give the title compound (0.05 g; 15.92%). MS (ES+): m/z=496 (M+H).

Provenance & Evidence