HCID 67264742, compound → HCID 59322388, compound

Participants

Reaction Steps

Combine 5-benzylidene-4-(4-(1-(2-dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl)-piperidin-1-yl)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (0.3 g; 0.00050 mol), PtO2/C (0.15 g; 0.00055 mol) in ethanol (5 mL) and stir under a hydrogen balloon atmosphere at 80° C. for 16 h. Cool the reaction to RT, filter through Celite® and concentrate. Purify over silica gel column using methanol in DCM as eluent to give the title compound (105 mg; 35%). MS (ES+): m/z=608 (M+1).

Provenance & Evidence