HCID 46186926, compound → HCID 87330609, compound

Participants

Reaction Steps

To a 20 mL scintillation vial fitted with stir bar charge with 211 mg of 4-{4-[1-(2-dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]piperidin-1-yl}-5,7-dihydro-pyrrolo[2,3-d]-pyrimidin-6-one, followed by 2 mL of a 3:1 IPA/H2O solvent mixture. Seed the suspension with 12 mg of hemihydrate seed crystals (see preparation below). Stir (˜600 RPM) at RT for approximately 4 days. Isolate the product by vacuum filtration.

Provenance & Evidence