1-(Isocyanatomethyl)-2-methylbenzene → HCID 86628143, compound

Participants

Reaction Steps

136 μl (0.98 mmol) of 2-methylbenzyl isocyanate were added to 150 mg (0.82 mmol) of 6-chloro-4-methyl-1H-pyrazolo[3,4-b]pyridin-3-ol in 10 ml of THF and 2 ml of DMF at room temperature. The reaction mixture was stirred at room temperature for 2 h and left to stand overnight. Concentration was followed by purification by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 139 mg (51%), M+H+: 331.18.

Provenance & Evidence