HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 6-Chloro-1,4-dimethyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid (R)-indan-1-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 86628149 | HCID 86628149 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Chloro-1,4-dimethyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid (R)-indan-1-ylamide | HCID 86628154 | — |
Reaction Steps
In analogy to example 2, 103 mg (0.3 mmol) of 6-chloro-4-methyl-3-oxo-1,3-dihydro-pyrazolo[3,4-b]pyridine-2-carboxylic acid (R)-indan-1-ylamide were reacted with 64 mg (0.45 mmol) of iodomethane in DMF with triethylamine. Yield: 56 mg (52%), M+H+: 357.09.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148395B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6cce54cfba954b83a782c4c1782ab8aa |
| Source note | uspto-grants-2012_04 |