HCID 59200382, compound → HCID 59200356, compound

Participants

Reaction Steps

To a solution of (25)-2-phenyl-1-{[(1S)-1-phenylethyl]amino}pentan-2-ol (0.954 g, 3.37 mmol) in EtOH (34 mL) was added Pd(OH)2/C (10%, 644 mg), then stirred at room temperature under 1 atmosphere of H2 overnight. The reaction was filtered through Celite, washed with EtOH, and the filtrate was concentrated to afford the desired product (609 mg, 100%) as an oil: 1H NMR (400 MHz, CDCl3) δ ppm 7.35-7.40 (2H, m), 7.32 (2H, t, J=7.71 Hz), 7.21 (1H, t, J=7.20 Hz), 3.10 (1H, d, J=12.38 Hz), 2.86 (1H, d, J=12.63 Hz), 2.58 (3H, s), 1.65-1.76 (2H, m), 1.28-1.39 (1H, m), 0.96-1.07 (1H, m), 0.82 (3H, t, J=7.33 Hz); [α]D20° C.=+4.2° (c=1, EtOH).

Provenance & Evidence