6-Methylpyridine-2-carbonitrile → HCID 59200350, compound

HRID 1685305Notes

Reaction equation

HRID 1685305 reaction equation
[NH2:1][CH2:2][C:3]([C:8]1[CH:13]=[C:12](C)[CH:11]=[CH:10][N:9]=1)([OH:7])[CH2:4][CH2:5][CH3:6].[CH3:15]C1N=C(C#N)C=CC=1.C([Mg]Br)CC>>[NH2:1][CH2:2][C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:15])[N:9]=1)([OH:7])[CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 3

HCID 741826-Methylpyridine-2-carbonitrileHCID 59200425HCID 59200425, compoundHCID 178455851HCID 178455851, compound

Product 1

HCID 59200350HCID 59200350, compound

Procedure

The title material was prepared as described for the synthesis of 1-amino-2-(4-methylpyridin-2-yl)pentan-2-ol (Example L) in using 6-methylpicolinonitrile and propyl magnesium bromide. LC/MS (M+H)+: 195. HPLC ret. time (Condition E): 1.068 min.

Workup

  1. custom1.068 min.

Sources & evidence

ORD record
ord-1dfa1fbc3868440999b0cfb85c59c4d5
Source dataset
uspto-grants-2012_04
Patent number
US08148400B2

Reaction notes

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