HCID 59200408, compound → HCID 59200344, compound

Participants

Reaction Steps

Benzyl 2-hydroxy-2,2-dim-tolylethylcarbamate (0.309 g, 0.823 mmol) was dissolved in ethanol (6 mL) and treated with 5% Pd/C (˜20 mgs). The reaction was stirred overnight under a hydrogen atmosphere (balloon). The reaction was filtered and the residue was purified on Biotage chromatography (10% to 60% methanol/dichloromethane) to give the title material (0.119 g, 60%) as an oil. 1H NMR (400 MHz, DMSO-d6) δ: 2.24 (6H, s), 3.16 (2H, ddd, J=3.16, 1.77 and 1.64 Hz), 4.27 (2H, s), 6.96 (2H, d, J=7.07 Hz), 7.15 (4H, m), 7.23 (2H, br s). LC/MS (M+H)+: 242. HPLC ret. time (Condition B): 1.328 min.

Provenance & Evidence