(2-(Methoxymethoxy)phenyl)(phenyl)methanone → 2-(2-(Methoxymethoxy)phenyl)-2-phenylethanamine

HRID 1685333Notes

Reaction equation

HRID 1685333 reaction equation
[C:1]1([CH:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2C)[CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][O:18][CH2:19][O:20]C1C=CC=CC=1C(C1C=CC=CC=1)=O>>[CH3:17][O:18][CH2:19][O:20][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH2:8][NH2:9]

Participants

3

Reactant 2

HCID 10444405(2-(Methoxymethoxy)phenyl)(phenyl)methanoneHCID 592004172-Phenyl-2-o-tolylethanamine

Product 1

HCID 592003532-(2-(Methoxymethoxy)phenyl)-2-phenylethanamine

Procedure

The title material was prepared as described for the synthesis of 2-phenyl-2-o-tolylethanamine (Example FF) in using (2-(methoxymethoxy)phenyl)(phenyl)methanone. 1H NMR (400 MHz, DMSO-d6) δ ppm: 6.88-7.44 (9H, m), 5.16-5.18 (1H, m), 5.09-5.15 (2H, m), 3.41-3.46 (2H, m), 3.21-3.23 (3H, m).

Sources & evidence

ORD record
ord-c76e6c17525c40618d15a53a9aab818c
Source dataset
uspto-grants-2012_04
Patent number
US08148400B2

Reaction notes

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