Potassium Phosphate, Tribasic → HCID 86639336, compound

Participants

Reaction Steps

Methanol (115 mL) was added to N-(5-nitropyridin-2-yl)-4-thiocyanatothiazol-2-amine (3.24 g, 11.6 mmol) and dithiothreitol (3.6 g, 23.3 mmol) at 23° C. Methyl 4-chloropicolinate (2.18 g, 12.8 mmol) was then added followed by potassium phosphate (3.27 g, 15.4 mmol) and DMF (115 mL). The reaction was stirred overnight, then poured into ice/water (1.5 L). The resulting precipitate was filtered on paper and dried under vacuum to give the title material (4.05 g, 90%). LC/MS (M+H)+: 390, (M−H)−: 388. HPLC ret. time (Condition E): 1.683 min.

Provenance & Evidence