Sodium Hydroxide → HCID 59200385, compound

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Reaction Steps

Methyl 4-(2-(5-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)pyridin-2-ylamino)thiazol-4-ylthio)picolinate (0.33 g, 0.608 mmol) in THF (5 mL) was treated with sodium hydroxide (1M, 2.4 mL, 2.4 mmol) at room temperature. The mixture was stirred for 30 minutes, then saturated ammonium chloride (20 mL) was added and the THF was evaporated. The solid was filtered to give the title material as a solid (0.32 g, 97%) which was used as is. LCMS (M+H)+: 529. HPLC ret. time (Condition A): 1.327 min.

Provenance & Evidence