Hydrochloric Acid → HCID 67265769, compound

Participants

Reaction Steps

H2O (0.30 g, 7.11 mmol) was added to a solution of methyl 2-benzyl-3-oxoisoindoline-5-carboxylate (Chemical Formula 7) (0.5 g, 1.78 mmol) in a mixture of 3:1:1(v/v/v) THF:methanol:H20 which was then stirred for 1 hour. The reaction progress was monitored using TLC [Hex:EA=1:1]. When the reaction was completed, the pH of the reaction mixture was adjusted to 4 with 1N HCl, followed by extraction with ethyl acetate. The organic layer thus obtained was dried over anhydrous MgSO4, filtered and concentrated in a vacuum to afford 2-benzyl-3-oxoisoindoline-5-carboxylic acid (Chemical Formula 8) at a yield of 85%.

Provenance & Evidence