2-Amino-4-methylbenzamide → HCID 57821998, compound

HRID 1685485Notes

Reaction equation

HRID 1685485 reaction equation
NC1C=C(C)C=CC=1C(N)=[O:5].NC(C1C=CC(C)=CC=1N[C:23]([C:25]1[N:26]=[C:27]([C:30]2[CH:31]=[N:32][CH:33]=[CH:34][C:35]=2[C:36]([F:39])([F:38])[F:37])[S:28][CH:29]=1)=[O:24])=O>>[F:37][C:36]([F:39])([F:38])[C:35]1[CH:34]=[CH:33][N:32]=[CH:31][C:30]=1[C:27]1[S:28][CH:29]=[C:25]([C:23]([OH:24])=[O:5])[N:26]=1

Participants

3

Reactant 2

HCID 28014742-Amino-4-methylbenzamideHCID 42639276HCID 42639276, compound

Product 1

HCID 57821998HCID 57821998, compound

Procedure

Reaction of intermediate III.1 and 2-amino-4-methylbenzamide and subsequent purification by HPLC in analogy to the synthesis of Example 1.1 results in N-[2-(aminocarbonyl)-5-methylphenyl]-2-[4-(trifluoromethyl)-3-pyridinyl]-4-thiazolecarboxamide as a solid.

Workup

  1. customto the synthesis of Example 1.1

Sources & evidence

ORD record
ord-8f9952afb5084bc0978db572588405e8
Source dataset
uspto-grants-2012_04
Patent number
US08148411B2

Reaction notes

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