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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1685490Generated: October 29, 2026

3,5-Dimethoxyaniline → 6-chloro-N-(3,5-dimethoxyphenyl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/1685490

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DimethoxyanilineHCID 66301—
Reactant6-Chloropyrazine-2-carbonyl chlorideHCID 15149671—
SolventDichloromethaneHCID 6344—
Product6-chloro-N-(3,5-dimethoxyphenyl)pyrazine-2-carboxamideHCID 16072436—

Reaction Steps

The product from Example 15B was reacted with 3,5-dimethoxyaniline and TEA in CH2Cl2 as described in Example 15C to afford the title compound. MS (DCI/NH3) m/z 294 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08148408B2
Source datasetuspto-grants-2012_04
ORD IDord-81f20c309dc347af9c51e2ae338518c7
Source noteuspto-grants-2012_04