HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → (3aR,6aS)-tert-butyl 5-(6-(3-methylbenzamido)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole | HCID 1514452 | — |
| Reactant | N-(6-chloropyrazin-2-yl)-3-methylbenzamide | HCID 86635811 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (3aR,6aS)-tert-butyl 5-(6-(3-methylbenzamido)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate | HCID 67265310 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
The product from Example 24A (130.5 mg, 0.53 mmol) was reacted with the product from Example 1C (149.6 mg, 0.70 mmol) and N,N-diisopropylethylamine (110 μL) in DMSO as described in Example 19A, except that the mixture was heated to 110° C. overnight, to afford the title compound. MS (DCI/NH3) m/z 424 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148408B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a7146ed984d441d695ed09ba805087df |
| Source note | uspto-grants-2012_04 |