2-Methylbenzylamine → 5-bromo-N-(2-methylbenzyl)nicotinamide

HRID 1685499Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH3:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14][NH2:15]>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:15][CH2:14][C:13]1[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=1[CH3:11])=[O:9]

Participants

Reactant 2

HCID 69932-Methylbenzylamine

HCID 887075-Bromonicotinic acid

Product 1

HCID 91046105-bromo-N-(2-methylbenzyl)nicotinamide

Procedure

Prepared from 5-bromonicotinic acid and 2-methylbenzylamine using procedures as described in Example 1H. MS (APCI) m/z 305, 307 (M+H)+.

Sources & evidence

ORD record: ord-99c63a9629254b158c6b6d1279d88249
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08148408B2

Reaction notes

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