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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1685505Generated: October 30, 2026

2-(2-Fluorophenyl)ethylamine → (3aR,6aS)-tert-butyl 5-(5-(2-fluorophenethylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

https://huagongshe.com/reaction/1685505

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2-Fluorophenyl)ethylamineHCID 643357—
Reactant5-((3aR,6aS)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)nicotinic AcidHCID 67265367—
Product(3aR,6aS)-tert-butyl 5-(5-(2-fluorophenethylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylateHCID 67265607—

Reaction Steps

The product from Example 33B and 2-(2-fluorophenyl)ethanamine were processed as described in Example 33C to provide the title compound. MS (ESI) m/z 455 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08148408B2
Source datasetuspto-grants-2012_04
ORD IDord-b13ab86f158a47bfa5b2fb73eb156728
Source noteuspto-grants-2012_04