3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid → HCID 11662931, compound

HRID 1685538Notes

Reaction equation

HRID 1685538 reaction equation
[CH:1]1([CH2:6][CH:7]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:21][C:22]1[S:23][C:24]([N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)=[CH:25][N:26]=1>>[CH:1]1([CH2:6][CH:7]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[C:8]([NH:21][C:22]2[S:23][C:24]([N:27]3[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]3)=[CH:25][N:26]=2)=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 120694893-Cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acidHCID 66520381HCID 66520381, compound

Product 1

HCID 11662931HCID 11662931, compound

Procedure

3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-[5-(4-methyl-piperazin-1-yl)-thiazol-2-yl]-propionamide was prepared from 3-cyclopentyl-2-(4-methanesulfonylphenyl)propionic acid and 2-amino-5-(4-methyl-piperazin-1-yl)thiazole as described in Example 1. 1H-NMR (CD3OD): δ 7.92 (d, 2H), 7.68 (d, 2H), 6.80 (s, 1H), 3.95 (t, 1H), 3.57 (m, 4H), 3.29 (m, 2H), 3.16 (m, 2H), 3.11 (s, 3H), 2.95 (s, 3H), 2.22-2.15 (m, 1H), 1.88-1.43 (m, 8H), 1.21-1.11 (m, 2H); HPLC-MS: m/z=477 (M+1).

Sources & evidence

ORD record
ord-b7ca9dbf71964cdfa356d5e18b947447
Source dataset
uspto-grants-2012_04
Patent number
US08148412B2

Reaction notes

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