Hydrochloric Acid → HCID 11662391, compound

Participants

Reaction Steps

{2-[3-Cyclopentyl-2-(4-methanesulfonylphenyl)-propionylamino]-5-methyl-thiazol-4-yl}-acetic acid ethyl ester (49 mg, 0.1 mmol), dioxan (0.5 mL), and 1 N sodium hydroxide were stirred at room temperature for 20 h. The pH was adjusted to approx. 3 with 1 N hydrochloric acid (0.5 mL), the reaction mixture was concentrated in vacuo, and the precipitate was isolated by filtration. Yellow crystals of the title compound were washed with water and dried to give 43 mg (yield: 93%). 1H-NMR (CDCl3): δ 7.85 (d, 2H), 7.58 (d, 2H), 3.78 (t, 1H), 3.62 (s, 2H), 3.01 (s, 3H), 2.42 (s, 3H), 2.22-2.15 (m, 1H), 1.93-1.86 (m, 1H), 1.75-1.49 (m, 7H), 1.15-1.02 (m, 2H); HPLC-MS: m/z=451 (M+1).

Provenance & Evidence