Water → HCID 11540597, compound

Participants

Reaction Steps

To a mixture of montmorillonite KSF (150 mg), water (50 μL), DCM (0.5 mL), and oxone (105 mg) was added a solution of {2-[3-cyclopentyl-2-(4-methanesulfonylphenyl)-propionylamino]-thiazol-5-ylsulfanyl}-acetic acid (32 mg, 68.3 mmol) in DCM (0.7 mL). The reaction mixture was stirred at room temperature for 18 hours, filtered and evaporated to dryness in vacuo to give the title compound as white crystals. Yield: 9 mg (25%). 1H-NMR (CDCl3): δ 7.83 (m, 3H), 7.51 (d, 2H), 4.21 (s, 2H), 3.81 (t, 1H), 3.00 (s, 3H), 2.14 (m, 1H), 1.88 (m, 1H), 1.69-1.38 (m, 8H), 1.06 (m, 2H); HPLC-MS: m/z: 501 (M+1).

Provenance & Evidence