2-(Methylsulfonyl)ethyl 4-methylbenzenesulfonate → 1-(2-Methanesulfonyl-ethyl)-1H-indole-3-carboxylic acid thiazol-2-ylamide

HRID 1685573Notes

Reaction equation

HRID 1685573 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)=[O:8].[CH3:18][S:19]([CH2:22][CH2:23]OS(C1C=CC(C)=CC=1)(=O)=O)(=[O:21])=[O:20]>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:23][CH2:22][S:19]([CH3:18])(=[O:21])=[O:20])[CH:10]=1)=[O:8]

Participants

3

Reactant 2

HCID 2843782-(Methylsulfonyl)ethyl 4-methylbenzenesulfonateHCID 17592646N-(1,3-thiazol-2-yl)-1H-indole-3-carboxamide

Product 1

HCID 595139801-(2-Methanesulfonyl-ethyl)-1H-indole-3-carboxylic acid thiazol-2-ylamide

Procedure

The title compound was prepared using 1H-indole-3-carboxylic acid thiazol-2-ylamide and toluene-4-sulfonic acid 2-methanesulfonyl-ethyl ester as R5X.

Sources & evidence

ORD record
ord-dfc14eae12604d899f194e27dbd9bae2
Source dataset
uspto-grants-2012_04
Patent number
US08148413B2

Reaction notes

Loading…