HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → Indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 6-(Trifluoromethyl)indole | HCID 2777523 | — |
| Reactant | Ethyl 2-(2-aminothiazol-5-ylthio)acetate | HCID 21455623 | — |
| Reactant | {2-[(1-Cyclopropylmethyl-6-fluoro-1H-indole-3-carbonyl)-amino]-thiazol-4-ylsulfanyl}-acetic acid | HCID 86610210 | — |
| Reactant | (2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester | HCID 86610213 | — |
| Product | Indole | HCID 798 | — |
Reaction Steps
6-trifluoromethylindole, R5X=cyclopropyl-methylbromide; NH2A=(2-amino-thiazole-5-ylsulfanyl)-propionic acid ethyl ester (prepared according to the procedure for the synthesis of (2-amino-thiazole-5-ylsulfanyl)-acetic acid ethyl ester described under the procedure for the synthesis of {2-[(1-Cyclopropylmethyl-6-fluoro-1H-indole-3-carbonyl)-amino]-thiazol-4-ylsulfanyl}-acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148413B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-769917b19b8443268b1c41989eb04abc |
| Source note | uspto-grants-2012_04 |