4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 59513957, compound

HRID 1685605Notes

Reaction equation

HRID 1685605 reaction equation
[CH2:1]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[C:13]([OH:15])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]([O:18][C:19](=[O:27])[CH2:20][C:21]1[N:22]=[C:23]([NH2:26])[S:24][CH:25]=1)[CH3:17]>>[CH2:16]([O:18][C:19](=[O:27])[CH2:20][C:21]1[N:22]=[C:23]([NH:26][C:13]([C:9]2[N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:12]=[CH:11][CH:10]=2)=[O:15])[S:24][CH:25]=1)[CH3:17]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 149858391-Benzyl-1H-pyrrole-2-carboxylic acid

Product 1

HCID 59513957HCID 59513957, compoundYield 65%

Procedure

(2-{[1-(Benzyl)-1H-pyrrole-2-carbonyl]-amino}-thiazol-4-yl)acetic acid ethyl ester (60 mg) was prepared from 1-benzyl-pyrrole-2-carboxylic acid (50 mg, 0.25 mmol) and 2-aminothiazol-4-yl acetic acid ethyl ester (47 mg, 0.25 mmol) following general procedure F.

Sources & evidence

ORD record
ord-a4149ba328484a56850384f8bee95df2
Source dataset
uspto-grants-2012_04
Patent number
US08148413B2

Reaction notes

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