4-Hydroxy-2-methoxybenzonitrile → HCID 178493524, compound

HRID 1685717Notes

Reaction equation

HRID 1685717 reaction equation
[CH3:1][C:2]1([CH3:21])[O:6][CH:5]([CH2:7][O:8][C:9]2[C:18](C)=[CH:17][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[CH:11][C:10]=2C)[CH2:4][O:3]1.[OH:22][C:23]1C=CC(C#N)=C(OC)C=1>>[CH3:21][C:2]1([CH3:1])[O:6][C@H:5]([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[C:17]([O:22][CH3:23])[CH:18]=2)[CH2:4][O:3]1

Participants

3

Reactant 2

HCID 109536814-Hydroxy-2-methoxybenzonitrileHCID 178426655HCID 178426655, compound

Product 1

HCID 178493524HCID 178493524, compound

Procedure

The title compound is obtained as a beige oil (2.46 g) in analogy to rac-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine starting from 4-hydroxy-2-methoxy-benzonitrile and L-alpha-beta-isopropyliden glycerol; LC-MS: tR=0.62 min, [M+H]+=296.97.

Sources & evidence

ORD record
ord-8463da072cea43a392cea42d24c23690
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

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