4-Cyanobenzenesulfonyl chloride → HCID 178472928, compound

HRID 1685725Notes

Reaction equation

HRID 1685725 reaction equation
[OH:1][NH:2][C:3](=[NH:17])[C:4]1[CH:9]=[CH:8][C:7]([S:10](=[O:16])(=[O:15])NCCO)=[CH:6][CH:5]=1.C(C1C=CC(S(Cl)(=O)=O)=CC=1)#N.Cl.[CH2:31]([O:33][C:34](=[O:37])[CH2:35][NH2:36])[CH3:32]>>[CH2:31]([O:33][C:34](=[O:37])[CH2:35][NH:36][S:10]([C:7]1[CH:6]=[CH:5][C:4]([C:3](=[NH:17])[NH:2][OH:1])=[CH:9][CH:8]=1)(=[O:16])=[O:15])[CH3:32]

Participants

4

Reactant 3

HCID 394974-Cyanobenzenesulfonyl chlorideHCID 2723640Glycine ethyl ester, hydrochlorideHCID 178513366HCID 178513366, compound

Product 1

HCID 178472928HCID 178472928, compound

Procedure

The title compound is prepared in analogy to N-hydroxy-4-(2-hydroxy-ethylsulfamoyl)-benzamidine starting from 4-cyano-benzenesulfonyl chloride and glycine ethyl ester hydrochloride; LC-MS: tR=0.27 min; [M+1]+=302.03;

Sources & evidence

ORD record
ord-fe9e811952e74c96a480ec9e3dd670f0
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

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