5-Formyl-4-methylthiophene-2-carboxylic acid → Rac-n-(3-{4-[5-(5-formyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide

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The title compound is prepared according to Method A starting from 5-formyl-4-methyl-thiophene-2-carboxylic acid and rac-2-hydroxy-N-{2-hydroxy-3-[4-(N-hydroxycarbamimidoyl)-2,6-dimethyl-phenoxy]-propyl}-acetamide; LC-MS: tR=0.90 min; [M+1]+=446.15; 1H NMR (D6-DMSO): δ 2.34 (s, 6H), 2.65 (s, 3H), 3.19-3.28 (m, 1H), 3.39-3.48 (m, 1H), 3.70-3.81 (m, 2H), 3.83 (d, J=5.8 Hz, 2H), 3.92-3.99 (m, 1H), 5.29 (d, J=5.5 Hz, 1H), 5.55 (t, J=6.0 Hz, 1H), 7.69 (m, 1H), 7.75 (s, 2H), 8.07 (s, 1H), 10.17 (s, 1H).

Provenance & Evidence