Diisopropylethylamine → HCID 67265665, compound

Participants

Reaction Steps

To a solution of 3-[2-ethyl-4-(5-{5-[(isopropyl-methyl-amino)-methyl]-4-methyl-thiophen-2-yl}-[1,2,4]oxadiazol-3-yl)-6-methyl-phenyl]-propionic acid formate salt (9 mg, 18 μmol) in DMF (1 mL), DIPEA (14.3 mg, 0.111 mmol) and TBTU (7 mg, 20 μmol) is added. The mixture is stirred for 5 min before glycine ethyl ester hydrochloride (3.9 mg, 28 μmol) is added. The mixture is stirred at rt for 1 h before it is separated by prep. HPLC to give the title compound (8 mg) as a pale yellow resin; LC-MS: tR=0.61 min; [M−1]−=527.19.

Provenance & Evidence