Dimethylamine → HCID 66829247, compound

Participants

Reaction Steps

The title compound (4 mg) is prepared starting from N-((2S)-3-{2-ethyl-4-[5-(5-formyl-4-methyl-thiophen-2-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide (12 mg, 26 μmol) and dimethylamine (14 mg, 105 μmol) according to Method C; LC-MS*: tR=0.80 min; [M+1]+=488.95; 1H NMR (D6-DMSO): δ1.23 (t, J=7.5 Hz, 3H), 2.23 (s, 3H), 2.26 (s, 6H), 2.35 (s, 3H), 2.73 (q, J=7.5 Hz, 2H), 3.21-3.29 (m, 1H), 3.39-3.47 (m, 1H), 3.61 (s, 2H), 3.71-3.81 (m, 2H), 3.84 (d, J=3.3 Hz, 2H), 3.93-4.00 (m, 1H), 5.31 (d, J=5.3 Hz, 1H), 5.55 (t, J=5.5 Hz, 1H), 7.68-7.72 (m, 2H), 7.77 (s, 2H).

Provenance & Evidence