5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid → 4-[5-(5-Diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-N-(2-hydroxy-ethyl)-benzenesulfonamide

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Reaction Steps

Starting from N-hydroxy-4-(2-hydroxy-ethylsulfamoyl)-benzamidine (201 mg, 0.774 mmol) and 5-diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid (160 mg, 0.704 mmol), the title compound (29 mg) is obtained as a yellow oil according to Method A; LC-MS: tR=0.49 min; [M+1]+=451.02; 1H NMR (CDCl3): δ1.27 (t, J=7.3 Hz, 6H), 2.34 (s, 3H), 2.91 (q, J=7.3 Hz, 4H), 3.17-3.22 (m, 2H), 3.73-3.77 (m, 2H), 4.11 (s, 2H), 7.74 (s, 1H), 8.01-8.04 (m, 2H), 8.24 (s br, 1H), 8.30-8.33 (m, 2H).

Provenance & Evidence