3-Hydroxypropionic acid → HCID 67265436, compound

HRID 1685766Notes

Reaction equation

HRID 1685766 reaction equation
[CH2:1]([N:3]([CH2:6][C:7]1[S:11][C:10]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][NH2:25])=[CH:19][CH:18]=3)[N:13]=2)=[CH:9][C:8]=1[CH3:26])[CH2:4][CH3:5])[CH3:2].[OH:27][CH2:28][CH2:29][C:30](O)=[O:31]>>[CH2:1]([N:3]([CH2:6][C:7]1[S:11][C:10]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][NH:25][C:28](=[O:27])[CH2:29][CH2:30][OH:31])=[CH:21][CH:22]=3)[N:13]=2)=[CH:9][C:8]=1[CH3:26])[CH2:4][CH3:5])[CH3:2]

Participants

3

Reactant 2

HCID 681523-Hydroxypropionic acidHCID 67265437HCID 67265437, compound

Product 1

HCID 67265436HCID 67265436, compoundYield 5%

Procedure

The title compound (3 mg) is prepared in analogy to Example 163 by coupling 2-{4-[5-(5-diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-ethylamine (50 mg, 135 μmol) with 3-hydroxypropionic acid (18 mg, 202 μmol); LC-MS: tR=0.71 min; [M+1]+=442.76.

Sources & evidence

ORD record
ord-f46418b8051b4b219db20156d381c2ed
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

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