Dimethylamine → HCID 136377326, compound

HRID 1685775Notes

Reaction equation

HRID 1685775 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:11]2[S:15][C:14]([C:16]3[S:20][C:19]([CH:21]=O)=[C:18]([CH3:23])[CH:17]=3)=[N:13][N:12]=2)[CH:6]=[C:7]([CH3:10])[C:8]=1[OH:9])[CH3:2].[CH3:24][NH:25][CH3:26]>C(O)C>[CH3:24][N:25]([CH2:21][C:19]1[S:20][C:16]([C:14]2[S:15][C:11]([C:5]3[CH:6]=[C:7]([CH3:10])[C:8]([OH:9])=[C:3]([CH2:1][CH3:2])[CH:4]=3)=[N:12][N:13]=2)=[CH:17][C:18]=1[CH3:23])[CH3:26]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 136377327HCID 136377327, compound

Product 1

HCID 136377326HCID 136377326, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound (13 mg) is prepared staring from 5-[5-(3-ethyl-4-hydroxy-5-methyl-phenyl)-[1,3,4]thiadiazol-2-yl]-3-methyl-thiophene-2-carbaldehyde (21 mg, 61 μmol) and dimethylamine (33 mg, 244 μmol, as a 33% solution in ethanol) according to Method C; LC-MS: tR=0.56 min; [M+1]+=374.07; 1H NMR (D6-DMSO): δ1.18 (t, J=7.3 Hz, 3H), 2.20 (s, 3H), 2.24 (s, 6H), 2.26 (s, 3H), 2.67 (q, J=7.3 Hz, 2H), 3.57 (s, 2H), 7.47 (s, 1H), 7.56 (s, 2H).

Sources & evidence

ORD record
ord-077095ad87434033bddea71d019ed72d
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

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