HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid → 2-Chloro-4-[5-(5-diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid | HCID 67265480 | — |
| Reactant | HCID 178426665 | HCID 178426665 | — |
| Product | 2-Chloro-4-[5-(5-diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol | HCID 136377330 | 24% |
Reaction Steps
The title compound (11 mg) is prepared starting from 5-diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid (30 mg, 130 μmol) and 4,N-dihydroxy-3-chloro-5-methyl-benzamidine (23 mg, 117 μmol) according to Method A; LC-MS: tR=0.60 min; [M+1]+=392.12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148410B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a01869cf07f94e308cba5144e4cf4666 |
| Source note | uspto-grants-2012_04 |