5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid → HCID 136377331, compound

HRID 1685784Notes

Reaction equation

HRID 1685784 reaction equation
[CH2:1]([N:3]([CH2:6][C:7]1[S:11][C:10]([C:12]([OH:14])=O)=[CH:9][C:8]=1[CH3:15])[CH2:4][CH3:5])[CH3:2].[OH:16][C:17]1[CH:26]=[CH:25][C:20]([C:21]([NH:23]O)=[NH:22])=[C:19]([O:27][CH3:28])[CH:18]=1>>[CH2:4]([N:3]([CH2:6][C:7]1[S:11][C:10]([C:12]2[O:14][N:23]=[C:21]([C:20]3[CH:25]=[CH:26][C:17]([OH:16])=[CH:18][C:19]=3[O:27][CH3:28])[N:22]=2)=[CH:9][C:8]=1[CH3:15])[CH2:1][CH3:2])[CH3:5]

Participants

3

Reactant 2

HCID 672654805-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acidHCID 178493425HCID 178493425, compound

Product 1

HCID 136377331HCID 136377331, compoundYield 16%

Procedure

The title compound (7 mg) is prepared starting from 5-diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid (30 mg, 130 μmol) and 4,N-dihydroxy-2-methoxy-benzamidine (21 mg, 117 μmol) according to Method A; LC-MS: tR=0.50 min; [M+1]+=374.12.

Sources & evidence

ORD record
ord-2a5db2789c554addb55cd578d94f2dc7
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

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