HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid → N-((2S)-3-{4-[5-(5-Diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2-methoxy-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid | HCID 67265480 | — |
| Reactant | (S)-2-Hydroxy-N-(2-hydroxy-3-[4-(N-hydroxycarbamimidoyl)-2-methoxy-6-methyl-phenoxy]-propyl)-acetamide | HCID 178492425 | — |
| Product | N-((2S)-3-{4-[5-(5-Diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2-methoxy-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide | HCID 66829278 | 9.9% |
Reaction Steps
The title compound (6 mg) is prepared starting from 5-diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid (30 mg, 130 μmol) and (S)-2-hydroxy-N-(2-hydroxy-3-[4-(N-hydroxycarbamimidoyl)-2-methoxy-6-methyl-phenoxy]-propyl)-acetamide (38 mg, 117 μmol) according to Method A; LC-MS: tR=0.51 min; [M+1]+=519.17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148410B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-1728d650fe96410296b84dd6a16a2478 |
| Source note | uspto-grants-2012_04 |